OVEREXPRESSION OF AURORA-A IN PRIMARY CELLS INTERFERES WITH S-PHASE ENTRY BY DIMINISHING CYCLIN D1 DEPENDENT ACTIVITIES

Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities

Abstract Background Aurora-A is a bona-fide oncogene whose expression is associated with genomic instability and malignant transformation.In several types of cancer, gene amplification and/or increased protein levels of Aurora-A are a common feature.Results In this report, we describe Electric Fireplace that inhibition of cell proliferation is the

read more

Detection of Mycoplasma anatis, M. anseris, M. cloacale and Mycoplasma sp. 1220 in waterfowl using species-specific PCR assays.

Mycoplasma anatis, M.anseris, M.cloacale and M.sp.1220 colonise geese and ducks, and could be associated with infections of avian respiratory and nervous systems, cause mild to severe inflammation of cloaca and genital tracts, and embryo lethality.Co-occurrence of these Mycoplasma species in waterfowl is frequently detected and the identification o

read more

Development of Acridone Derivatives: Targeting c-MYC Transcription in Triple-Negative Breast Cancer with Inhibitory Potential

Breast cancer, especially the aggressive triple-negative subtype, poses a serious health threat to women.Unfortunately, effective targets are lacking, leading to a grim prognosis.Research highlights the crucial role of c-MYC overexpression in this form of cancer.Current inhibitors targeting c-MYC focus on stabilizing its G-quadruplex Coffee Bean (G

read more

Resurrection of Diplostomum numericum Niewiadomska, 1988 (Digenea, Diplostomatoidea: Diplostomidae) Based on Novel Molecular Data from the Type-Host

Diplostomum is a taxonomically problematic genus of trematodes, with many members harmful at the metacercarial stage to fish in aquaculture.We found metacercariae in the eye vitreous humor of the rudd, Scardinius erythrophthalmus; the Chokes bleak, Alburnus alburnus; and the roach, Rutilus rutilus, in Karelia (Russia) and identified them as Diplost

read more